Using big data from NACC to construct a predictive models of Alzheimer's disease. Lead Investigator: Mingjian Shi Institution : Vanderbilt University E-Mail : mingjian.shi@vanderbilt.edu Proposal ID : 901 Proposal Description: To identify the contributors to Alzheimer: age, sex, weight, height, diet, life habit, genes(APP, ApoE), diseases(hypertension, hypercholesterolemia, and obesity, diabetes) and family history of AD Genetic Risk or Environmental Lifestyle Factors? The specific aims: 1. Using R program to generate the basic descriptive and inferential statistics of control and AD group. 2. Build a predictive (regression) models of AD and to identify the main contributors to this disease. 3. Apply the built regression models to identify the high risk population.